Alteration of cytokine profile following hemorrhagic shock
نویسندگان
چکیده
منابع مشابه
Apoptotic signaling induces hyperpermeability following hemorrhagic shock.
Hemorrhagic shock (HS) disrupts the endothelial cell barrier, resulting in microvascular hyperpermeability. Recent studies have also demonstrated that activation of the apoptotic signaling cascade is involved in endothelial dysfunction, which may result in hyperpermeability. Here we report involvement of the mitochondrial "intrinsic" pathway in microvascular hyperpermeability following HS in ra...
متن کاملPost-hemorrhagic shock mesenteric lymph is an important contributor to cardiac dysfunction following hemorrhagic shock.
PURPOSE To evaluate whether post-hemorrhagic shock mesenteric lymph (PSML) is involved in cardiac dysfunction induced by hemorrhagic shock. METHODS The hemorrhagic shock model (40±2 mmHg, 3h) was established in rats of the shock and shock+drainage groups; and PSML drainage was performed from hypotension 1-3h in the shock+drainage rats. Then, the isolated hearts were obtained from the rats for...
متن کاملthe myocardial factor in irreversible hemorrhagic shock: alterations of myocardial performance of the isolated canineheart preparation following irreversible hemorrhagic shock
myocardial performance, utilizing the isolated canine heart preparation, was studied in two groups: normal control dogs and those subjected to hemorrhagic shock. a marked deterioration in myocardial functional capacity was observed in the shock group. from this study, myocardial incapacity resulting from the period of acute hypotension is felt to be a contributing factor in the death of animals...
متن کاملTh1, Th2 and Th17 Cytokine Profile in Patients with Multiple Sclerosis Following Treatment with Rapamycin
Background: Management of multiple sclerosis (MS) is based on the usage of immunosuppressive and immune-modulating medications. Cytokines play an important role in the pathogenesis of MS. Objective: To evaluate the effects of rapamycin on the concentrations of Th1/Th2/Th17 serum cytokines in patients with MS. Methods: Six patients with relapsing remitting MS as a case group and 6 healthy indivi...
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ژورنال
عنوان ژورنال: Cytokine
سال: 2016
ISSN: 1043-4666
DOI: 10.1016/j.cyto.2016.01.022